CytoDyn (NASDAQ: CYDY) today announced that its vice chairman and chief science officer, Denis R. Burger, Ph.D, will later this week provide an update on the pivotal Phase 2b/3 trial with PRO 140 as a combination therapy in treatment-experienced HIV patients at the ASM Microbe 2017 Conference. An abstract of the pivotal Phase 2b/3 study is expected to be available online after the conference concludes. To date, PRO 140 has been evaluated in more than 300 HIV patients in various studies. It has shown potent antiviral activity with HIV patients infected with the R5 strain of HIV, which accounts for approximately 70% of HIV infected patients and up to 90% of those newly diagnosed.
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CytoDyn is a biotechnology company focused on the clinical development and potential commercialization of humanized monoclonal antibodies for the treatment and prevention of HIV infection. The Company has one of the leading monoclonal antibodies under development for HIV infection, PRO 140, which has completed Phase 2 clinical trials with demonstrated antiviral activity in man and is currently in Phase 3. PRO 140 blocks the HIV co-receptor CCR5 on T cells, which prevents viral entry. Clinical trial results thus far indicate that PRO 140 does not negatively affect the normal immune functions that are mediated by CCR5. Results from seven Phase 1 and Phase 2 human clinical trials have shown that PRO 140 can significantly reduce viral burden in people infected with HIV. A recent Phase 2b clinical trial demonstrated that PRO 140 can prevent viral escape in patients during several months of interruption from conventional drug therapy. CytoDyn intends to continue to develop PRO 140 as a therapeutic anti-viral agent in persons infected with HIV and to pursue non-HIV indications where CCR5 and its ligand CCL5 may be involved. For more information on the Company, please visit www.cytodyn.com.
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