Bellerophon Therapeutics (NASDAQ: BLPH) this morning reported positive top line data from its phase 2 clinical trial evaluating INOpulse® in patients with Pulmonary Hypertension Associated with Chronic Obstructive Pulmonary Disease (PH-COPD). The phase 2 study was designed to measure the acute effect of pulsed inhaled nitric oxide (iNO) on targeted vasodilation, as well as the chronic effect (4 weeks) of iNO on hemodynamics and exercise capacity. The acute effect results show statistically significant increases in blood vessel volume on iNO compared to baseline. Additionally, the chronic results demonstrated statistically significant and clinically meaningful increases in six-minute walking distance compared to baseline. “These compelling data confirm and build upon the results from our previous acute studies, and reaffirm INOpulse’s potential role as a first-in-class therapy for PH-COPD patients,” Bellerophon CEO Fabian Tenenbaum stated in the news release.
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Bellerophon Therapeutics is a clinical-stage biotherapeutics company focused on developing innovative therapies at the intersection of drugs and devices that address significant unmet medical needs in the treatment of cardiopulmonary diseases. The company is currently developing three product candidates under its INOpulse program, a proprietary pulsatile nitric oxide delivery system. The first is for the treatment of pulmonary arterial hypertension (PAH), for which the company has commenced phase 3 clinical trials. The second is for the treatment of pulmonary hypertension associated with chronic obstructive pulmonary disease (PH-COPD) and the third candidate is for the treatment of pulmonary hypertension associated with Interstitial Lung Disease (PH-ILD), both of which are in phase 2 development. For more information, please visit www.bellerophon.com
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